Foster Neo and Bio Genesis
Strengthen immunity and fight off illnesses
Reduce blood fat by up to 75%, control weight, and help recover and repair the body
We provide topical creams for hormone replacements solutions
Improve aging bio-markers such as Telomere length, AKG and NAD levels
Activate and connect network systems responsible for health and damage response
Kimura et al. (2022) reported that NMN administration led to a significant increase in total NAD+ levels after 2 hours Grant et al. (2019) found that a continuous infusion of NAD+ resulted in a significant increase in plasma NAD+ levels only at the end of the infusion after 6 hours. Per the study authors “Unexpectedly, however in NAD+ infused participants, plasma NAD+ levels failed to rise until after the 2 h time point” indicating that IV administered NAD+ fails to cross the cell membrane intact and instead resulted in complete metabolism of NAD+ and its metabolites in plasma which then in turn crossed the cell membrane and contributed to only a modest increase
NAD+ metabolism. Extracellular NAD+ is catabolized into precursors (NMN and others) by CD73. NMN and NR enter the cell through active and/or passive transport.
IV administration of NR and NMN has been shown in several studies to be the superior method for elevating tissue NAD+ levels. Taken together, these findings highlight the importance of considering the route of administration when designing interventions aimed at elevating tissue NAD+ levels. IV administration of NMN and NR has been shown to be the superior method compared to oral administration and IV administration of NAD+. While oral administration of NR and NMN has poor bioavailability, NMN and NR can effectively cross the cell membrane and elevate tissue NAD+ levels when delivered intravenously. These findings suggest that IV administration of NMN and NR should be considered as a preferred method for elevating tissue NAD+ levels
References